The Importance of the Gut Microbiome
These intestinal organisms—including “good bacteria”—help your body by:2,3
- Contributing nutrients and energy
- Protecting against infection
- Supporting the immune system
When the environment inside your intestine is functioning the way it should, this stable state between the gut microbiome and the intestinal lining is called gut homeostasis.
The gut microbiome can be upset by different factors
When a person has chronic diarrhea and loose stools due to specific intestinal disorders like irritable bowel syndrome with diarrhea (IBS-D), or inflammatory bowel disease (IBD), different factors may upset the delicate balance between the microbiome and the integrity of the intestinal lining, such as:2-9
- Overgrowth of bacteria in the small intestines. While most bacteria typically reside in the large intestine, difficulty can arise when too many bacteria reside in a person’s small intestine (resulting in small intestinal bacterial overgrowth, also known as SIBO)
- Exposure to foreign substances called antigens (which cause the immune system to create antibodies against them)
- External insults like infection or other illnesses
- Certain dietary ingredients (like lactose in milk products)
When such events occur in the intestinal environment, scientists refer to these changes as altered gut microbiota or intestinal balance (also known as dysbiosis). Inflammation can also lead to microscopic changes at the cellular level in the intestinal lining (also called the intestinal or gut barrier), which can prevent proper absorption of nutrients and water.2
Increases in “leaky gut” can cause problems
You may have heard of “leaky gut syndrome,” which is also known by the medical term of gut barrier dysfunction and altered gut permeability. When your gut barrier is not functioning properly, foreign or even naturally occurring substances that may be toxic to your gut (ie, bacterial endotoxins) can penetrate (get into) the lining of your intestine. This may contribute to symptoms such as:2,4,5,8,9
- Chronic diarrhea and loose stools
- Abdominal discomfort
Address the underlying problem
Imagine how your life might be different if you could:
- Address the underlying factors that may contribute chronic diarrhea and loose stools due to specific intestinal disorders instead of just trying to minimize them
- Help manage harmful substances—such as toxic substances released by bacteria and other microbial components—from penetrating the lining of your intestine and upsetting your intestinal environment
- Do all this with a safe therapy that can be taken alone, or along with any other medications, for as long as you want (under your doctor’s supervision)9
If this is what you are hoping for, ask your doctor about EnteraGam®. EnteraGam® is a medical food product that is not an antibiotic or a probiotic.
- Wu GD, Lewis JD. Analysis of the human gut microbiome and association with disease. Clin Gastroenterol Hepatol. 2013;11(7):774-777.
- Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy. Clin Exp Gastroenterol. 2014;7:181-190.
- Gut bacteria andIBS. International Foundation for Functional Gastrointestinal Disorders Website. http://www.aboutibs.org/gut-bacteria-and-ibs.html. Published May 10, 2016. Accessed February 5, 2017.
- Kornbluth A, Sachar DB; Practice Parameters Committee of the American College of Gastroenterology. Ulcerative colitis practice guidelines in adults: American College of Gastroenterology, Practice Parameters Am J Gastroenterol. 2010;105(3):501-523.
- Lichtenstein GR, Hanauer SB, Sandborn WJ; Practice Parameters Committee of American College of Gastroenterology. Management of Crohn’s disease in adults. Am J Gastroenterol. 2009;104(2):465-483.
- Irritable bowel syndrome. Mayo Clinic Website. http://www.mayoclinic.org/diseases-conditions/irritable-bowel-syndrome/basics/definition/con-20024578. Published July 31, 2014. Accessed February 5, 2017.
- Gut microbiome points to cures and treatment for IBD. Crohn’s & Colitis Foundation of America Website. http://www.ccfa.org/news/gut-microbiome-points-to.html. Published July 29, 2014. Accessed February 5, 2017.
- Gasbarrini A, Lauritano EC, Garcovich M, Sparano L, Gasbarrini New insights into the pathophysiology of IBS: intestinal microflora, gas production and gut motility. Eur Rev Med Pharmacol Sci. 2008;12 Suppl 1:111-117.
- EnteraGam® [product information]. Ankeny, IA: Entera Health, Inc.; October 2020.
EnteraGam® is a medical food product intended for the dietary management of chronic diarrhea and loose stools. EnteraGam® must be administered under medical supervision.
Important Safety Information
EnteraGam® contains beef protein: therefore, patients who have an allergy to beef or any other component of EnteraGam® should not take this product. EnteraGam® has not been studied in pregnant women, in women during labor and delivery, or in nursing mothers. The choice to administer EnteraGam® during pregnancy, labor and delivery, or to nursing mothers is at the clinical discretion of the prescribing physician.
EnteraGam® does not contain any milk-derived ingredients such as lactose, casein, or whey. EnteraGam® is gluten-free, dye-free, and soy-free.
Please see Full Product Information.
To report suspected adverse reactions, contact Entera Health, LLC at 1-855-4ENTERA (1-855-436-8372), or the FDA at 1-800-FDA-1088 (1-800-332-1088) or www.fda.gov/medwatch.
EnteraGam® is manufactured and
distributed by Entera Health, LLC.
©2021 Entera Health, LLC.
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The product information provided in this site is intended for residents of the United States.