FAQs About EnteraGam®

General product information

What is EnteraGam®?

EnteraGam® is a medical food product for the dietary management of chronic diarrhea and loose stools due to specific intestinal disorders like irritable bowel syndrome with diarrhea (IBS-D) and inflammatory bowel disease (IBD). Read About EnteraGam® to learn more.

What is medical food?
How can EnteraGam® help?
How many packets are in a box?

Each box of EnteraGam® has 30 packets in it.

What is the bacteria count in millions in a packet of EnteraGam®?
Is EnteraGam® safe?
Why must EnteraGam® be taken under physician supervision? Can it be dangerous?


How it works

How does EnteraGam® work?
If Cholestyramine has helped in the past, do you think EnteraGam® will help now?



Does EnteraGam® help with gas?
Can EnteraGam® be used for diarrhea that comes from c difficile?
Is EnteraGam® still helpful to patients even if they don’t have diarrhea/loose stools?
Can EnteraGam® be used for constipation?



Can EnteraGam® be used for IBS with constipation?
Does EnteraGam® help with leaky gut?
Does EnteraGam® help with a bowel obstruction?
Will EnteraGam® work for a person with microscopic colitis?
Will EnteraGam® work for a person with hydrogen dominant SIBO?
Will EnteraGam® help with H2S bacteria overgrowth?
Will EnteraGam® work for a person with Crohn’s disease? Has it been studied in connection with Crohn’s?
Will EnteraGam® work for a person with terrible fibromyalgia pain post osteomyelitis and its treatment?
Will taking EnteraGam® help with my lactose intolerance?


Probiotics and antibiotics

How is EnteraGam® different from probiotics?
How is EnteraGam® different from antibiotics?

EnteraGam® is not an antibiotic. Antibiotics can contribute to diarrhea by damaging the microbiome which leads to gut barrier disruption or leaky gut. Antibiotics are also not safe for long-term use for IBS-D, which is often a chronic condition.10 You can take EnteraGam® as long as you want, and you do not need any special blood tests or other monitoring tests. And with EnteraGam®, you do not have to worry about bacterial resistance like you do with antibiotics.8,10  See About EnteraGam® to learn more.


Use with other health products

Can I use EnteraGam® with other therapies?

EnteraGam® can be safely taken along with other therapies for chronic diarrhea and loose stools that your doctor has prescribed. EnteraGam® can also be safely taken with any other medications or therapies for other conditions.8 Learn more about the safety of EnteraGam®.

Should I avoid using supplements when taking EnteraGam®?
Is taking probiotics together with EnteraGam® advised or contraindicated?
Do you have any information on results or testimonials or reviews about people that take EnteraGam® with Humira®?
Can EnteraGam® be taken with Xifaxan®?
Can I continue to take MiraLAX® while taking EnteraGam®?
Can I continue taking Lactaid® while I take EnteraGam®?
Can EnteraGam® be taken with other commonly prescribed medications for IBS-D, such as Imodium®, probiotics, and dicyclomine?



What is the full ingredients list for EnteraGam® – active and inactive ingredients?
Is EnteraGam® safe for a dairy-free, lactose-free, corn-free, soy-free diet?
Does EnteraGam® contain corn or corn-derived ingredients?
Does EnteraGam® contain nuts or nut-derived ingredients?
Is EnteraGam® gluten free?
Is there a vegetarian (non-animal based) version of this product?
What is the source of the dextrose in EnteraGam®?
Is there a dextrose-free version of EnteraGam® available or planned?


Taking EnteraGam®

How do I take EnteraGam®?
How long can I take EnteraGam®?
How many packets a day is a patient supposed to take?
Is it best to take EnteraGam® on an empty stomach or with food?
How much time after a dose of EnteraGam® can I eat?
Should I take EnteraGam® with a snack during the day when I don’t have other vitamins & enzymes?
Which is better/most recommended for the first 2 weeks: 1 twice daily or 2 once daily?
Is it okay to mix two packages in one dose?
When I split a package of EnteraGam®, how much is that per each of 2 servings? Is it 1 teaspoon?
Is it okay to take EnteraGam® beyond its expiration date? If so, how far past? Is there a danger if taken far beyond the expiration date?
What is the reason EnteraGam® cannot be shaken? Is it ok to mix it with a hand blender?
When I mix EnteraGam® in water, there is always some foam left over at the bottom after I drink all the fluid. Is it imperative that I drink the foam in order to get the full dose?
Does it really make it less effective if I mix EnteraGam® in a bottle and drink it 4 or more hours later?
Is there any reason why I can’t put EnteraGam® into an empty gelatin capsule and take it with water?
How long do I have to wait to drink hot liquids after I consume EnteraGam®?


Timing for taking EnteraGam®

Is EnteraGam® something you take every day or only during flare-ups?
Should EnteraGam® be taken at the same time each day?
Should EnteraGam® be taken in the morning or evening?
Should EnteraGam® be taken before or after a meal?
What is the best time of day to take EnteraGam® two times a day?
What is the best time of day to take EnteraGam® once a day?


What can be taken with EnteraGam®

Why should EnteraGam® not be mixed with citrus juice?
Is it best to take EnteraGam® with room-temperature water?
Is it okay to mix EnteraGam® with hot tea?
Is it okay to mix EnteraGam® with pudding?
Is it okay to mix EnteraGam® with applesauce?
Is it okay to mix EnteraGam® with (lactose-free) milk?
Is it okay to mix EnteraGam® with pineapple juice?
Is it okay to mix EnteraGam® with Cran-lite cranberry or other cranberry juice?
Is it okay to mix EnteraGam® with Pedialyte®?
Is EnteraGam® something I can mix into my morning smoothie that contains fruit, greens & protein powder?
Can EnteraGam® be taken at the same time as a powder glutamine supplement and/or a powdered probiotic? Can we mix EnteraGam® with either of these in the same liquid?


Getting EnteraGam®

Where can I get EnteraGam®?

If you still have questions about EnteraGam®contact us and we’ll be happy to answer any additional questions you may have. 

  1. Horgan A, Maas K, Henderson A, Detzel C, Weaver E. Serum-derived bovine immunoglobulin/protein isolate binds to pathogen-associated molecular patterns. Poster presented at: Federation of American Societies for Experimental Biology; April 26-30, 2014; San Diego, CA.
  2. Asmuth D, Netanya S. Utay NS, Somsouk M, et al. Oral bovine immunoglobulin reduces immune activation in HIV+ immune nonresponders. Poster presented at: Conference on Retroviruses and Opportunistic Infections (CROI); February 22-25, 2016; Boston, MA.
  3. Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy. Clin Exp Gastroenterol. 2014;7:181-190.
  4. Henderson AL, Brand MW, Darling RJ, et al. Attenuation of colitis by serum-derived bovine immunoglobulin/protein isolate in a defined microbiota mouse model. Dig Dis Sci. 2015;60(11):3293-3303.
  5. Pérez-Bosque A, Miró L, Maijó M, et al. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. Am J Physiol Gastrointest Liver Physiol. 2015;308(12):G1012-G1018.
  6. Pérez-Bosque A, Miró L, Maijó M, et al. Oral serum-derived bovine immunoglobulin/protein isolate has immunomodulatory effects on the colon of mice that spontaneously develop colitis. PLoS One. 2016;11(5):e0154823.
  7. Detzel CJ, Horgan A, Henderson AL, Petschow BW, Warner CD, Maas KJ, Weaver EM. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015;10(4):e0120278.
  8. EnteraGam® [product information]. Ankeny, IA: Entera Health, Inc.; October 2020.
  9. Wilson D, Evans M, Weaver E, Shaw AL, Klein GL. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013;6:49-60.
  10. Xifaxan® [prescribing information]. Raleigh, NC: Salix Pharmaceuticals, Inc.; May 2015.
  11. Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks? Am J Clin Nutr. 2006;83(6):1256-1264.
  12. Sartor RB, Mazmanian SK. Intestinal microbes in inflammatory bowel diseases. Am J Gastroenterol Suppl. 2012;1(1):15-21.
  13. Morgan SL, Baggott JE. Medical foods: products for the management of chronic diseases. Nutr Rev. 2006;64(11):495-501.

Intended Use

EnteraGam® is a medical food product intended for the dietary management of chronic diarrhea and loose stools. EnteraGam® must be administered under medical supervision.

Important Safety Information

EnteraGam® contains beef protein: therefore, patients who have an allergy to beef or any other component of EnteraGam® should not take this product. EnteraGam® has not been studied in pregnant women, in women during labor and delivery, or in nursing mothers. The choice to administer EnteraGam® during pregnancy, labor and delivery, or to nursing mothers is at the clinical discretion of the supervising physician.

EnteraGam® does not contain any milk-derived ingredients such as lactose, casein, or whey. EnteraGam® is gluten-free, dye-free, and soy-free.

Please see Full Product Information.

To report suspected adverse reactions, contact Entera Health, LLC at 1-855-4ENTERA (1-855-436-8372), or the FDA at 1-800-FDA-1088 (1-800-332-1088) or www.fda.gov/medwatch.

EnteraGam® is manufactured and
distributed by Entera Health, LLC.
©2022 Entera Health, LLC.
Ankeny, IA 50021
ENT100P0121 01/22

The product information provided in this site is intended for residents of the United States.