EnteraGam® Mechanism of Action (MOA)
To best explain how EnteraGam® works, we start with a review of the factors that can cause chronic diarrhea and loose stools in patients with specific intestinal disorders.
Watch the animation to the right or click on the expand arrow on either of the sections below to learn more.
Altered Gut Microbiota: An Important Underlying Etiology of Chronic Loose and Frequent Stools
Chronic diarrhea and loose stools due to specific intestinal disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), often result from alterations to the gut microbiome.
The involvement of genetic predispositions, diet, stress, and exposure to external antigens, toxins, or environmental insults (including infection) may combine to trigger a continuing cycle of altered gut microbiota, immune activation (resulting in inflammation), gut barrier dysfunction with permeability changes, and impaired nutrient absorption which serves to further amplify and prolong this cycle of events. (See figure below)
Nonclinical1 and clinical studies2,3 suggest that immunoglobulin-containing protein preparations, such as that found in EnteraGam®, fulfill a distinct nutritional requirement for patients with chronic diarrhea and loose stools due to specific intestinal disorders that cannot be provided by other dietary protein sources or by a simple dietary change.
A growing body of evidence suggests that the specially formulated distinct nutrition of the immunoglobulins found in EnteraGam® plays a key role in providing nutrients to the appropriate areas of the GI tract to help maintain homeostasis of normal intestinal processes in patients with chronic diarrhea and loose stools due to specific intestinal disorders, such as IBS-D2 and IBD.4-7 Specifically, these immunoglobulins and other plasma proteins may help maintain normal intestinal digestion, absorption, and metabolism of ordinary foodstuffs and certain nutrients. EnteraGam® has been shown to: bind microbial components, maintain GI immune balance, manage gut barrier function, and improve nutrient utilization (see figure below).8-15
EnteraGam® is a medical food* product intended for the dietary management of chronic diarrhea and loose stools.
EnteraGam® must be administered under medical supervision.
*Medical foods are regulated by the FDA under the Orphan Drug Act16; specially formulated to be consumed or administered orally or enterally; to be used under physician supervision as part of ongoing care to ensure proper, safe use; specifically for management of distinctive nutrient needs, resulting from a specific chronic condition or disease; and specially formulated and processed, as results are not achievable by normal dietary intake.