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EnteraGam® is Unlike Anything Else for IBS-D

Tired of rearranging your days around abdominal discomfort, bloating, or chronic diarrhea—or having to cancel plans altogether? EnteraGam® may help manage your condition.

EnteraGam® is a medical food product that is completely different from other therapies because it uniquely addresses the underlying factors that may contribute to symptoms of irritable bowel syndrome with diarrhea (IBS-D). Some people notice management of their condition with EnteraGam® in as little as 2 to 4 weeks.1

Works right at the source of the problem

When you have IBS-D, different factors can upset the environment in your intestine altering the gut microbiota or organisms called microbes (also known as an altered gut microbiome). An altered microbiome may contribute to inflammation which causes small gaps at a cellular level in the intestinal lining (called the intestinal or gut barrier).2

When substances (both foreign or natural) that may be toxic to the gut penetrate the lining of your intestine, they may contribute to symptoms of IBS-D, including chronic diarrhea and loose stools.2,3

EnteraGam® uniquely binds toxic substances released by bacteria (and other substances called microbial components4) that upset the intestinal environment. This helps prevent them from penetrating the lining of the intestine and causing problems. EnteraGam® may also help2,5-10:

  • Restore a stable environment in your gut (called gut homeostasis)
  • Manage how your gut barrier works (called gut barrier function) so nutrients from foods and fluids can be properly absorbed

EnteraGam® helps you avoid having to rearrange or cancel your plans due to your condition. In a clinical study, people who took EnteraGam® experienced fewer days per week with loose stools and other IBS-D related symptoms, including abdominal discomfort and bloating. Some people notice management of their condition with EnteraGam® in as little as 2 to 4 weeks.1

EnteraGam® is a fine powder that can be easily mixed into at least 4 ounces of liquid (water or other liquid as preferred). Alternatively, EnteraGam® can be mixed with soft foods, such as pudding or yogurt. Your doctor will determine your starting dose of EnteraGam® based on the number of loose or watery stools you have per day. Anywhere from 1 to 4 packets per day may be recommended.10 

 

EnteraGam® is safe, well tolerated, and can be taken along with other therapies for IBS-D that your doctor has prescribed. EnteraGam® can also be safely taken with medications or therapies for other conditions.10


Take action today

Print this free Doctor Discussion Guide and ask your doctor if EnteraGam® is right for you. Your doctor may want you to take EnteraGam® along with your other IBS-D therapies.


Easy to take

References
  1. Wilson D, Evans M, Weaver E, Shaw AL, Klein GL. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013;6:49-60.
  2. Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy. Clin Exp Gastroenterol. 2014;7:181-190.
  3. Gasbarrini A, Lauritano EC, Garcovich M, Sparano L, Gasbarrini New insights into the pathophysiology of IBS: intestinal microflora, gas production and gut motility. Eur Rev Med Pharmacol Sci. 2008;12 Suppl 1:111-117.
  4. Horgan A, Maas K, Henderson A, Detzel C, Weaver E. Serum-derived bovine immunoglobulin/protein isolate binds to pathogen-associated molecular patterns. Poster presented at: Federation of American Societies for Experimental Biology; April 26-30, 2014; San Diego, CA.
  5. Asmuth D, Netanya S. Utay NS, Somsouk M, et al. Oral bovine immunoglobulin reduces immune activation in HIV+ immune nonresponders. Poster presented at: Conference on Retroviruses and Opportunistic Infections (CROI); February 22-25, 2016; Boston, MA.
  6. Henderson AL, Brand MW, Darling RJ, et al. Attenuation of colitis by serum-derived bovine immunoglobulin/protein isolate in a defined microbiota mouse model. Dig Dis Sci. 2015;60(11):3293-3303.
  7. Pérez-Bosque A, Miró L, Maijó M, et al. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. Am J Physiol Gastrointest Liver Physiol. 2015;308(12):G1012-G1018.
  8. Pérez-Bosque A, Miró L, Maijó M, et al. Oral serum-derived bovine immunoglobulin/protein isolate has immunomodulatory effects on the colon of mice that spontaneously develop colitis. PLoS One. 2016;11(5):e0154823.
  9. Detzel CJ, Horgan A, Henderson AL, Petschow BW, Warner CD, Maas KJ, Weaver EM. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015;10(4):e0120278.
  10. EnteraGam® [product information]. Ankeny, IA: Entera Health, Inc.; October 2020.

Intended Use

EnteraGam® is a medical food product intended for the dietary management of chronic diarrhea and loose stools. EnteraGam® must be administered under medical supervision.

Important Safety Information

EnteraGam® contains beef protein: therefore, patients who have an allergy to beef or any other component of EnteraGam® should not take this product. EnteraGam® has not been studied in pregnant women, in women during labor and delivery, or in nursing mothers. The choice to administer EnteraGam® during pregnancy, labor and delivery, or to nursing mothers is at the clinical discretion of the supervising physician.

EnteraGam® does not contain any milk-derived ingredients such as lactose, casein, or whey. EnteraGam® is gluten-free, dye-free, and soy-free.

Please see .

To report suspected adverse reactions, contact Entera Health, LLC at 1-855-4ENTERA (1-855-436-8372), or the FDA at 1-800-FDA-1088 (1-800-332-1088) or www.fda.gov/medwatch.

EnteraGam® is manufactured and
distributed by Proliant Health & Biologicals, LLC.
©2023 Proliant Health & Biologicals, LLC.
Ankeny, IA 50021
ENT100P0121 01/22

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